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Some laboratories report may show a very high result as greater than a stated upper limit rather than as a precise number

47,75,76,77 Recently, we reported that GH promotes radioresistance in cancer cell lines 78 and that pegvisomant suppresses endometrial tumor regrowth following radiotherapy in a xenograft model, which highlights the potential utility of this combinational approach and identifies GHR antagonism as a potential molecularly targeted radiosensitizing strategy

(PubMed) Checchi S, Montanaro A, Ciuoli C, et al

In the clinical setting, TP508 has failed to display the same beneficial effects as in animal studies

They establish, convincingly, that the molecule does what its designers intended at the receptor level, and they generate strong hypotheses about human physiology