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This happened when totally inconsistent results were published by several groups using JNK2-deficient mice [36, 134136] and it was later discovered that the reason for the contradictory data was caused by the mislabeling of the background strain for JNK2 KO mice by the vendor [137], which led to the use of WT and KO mice with mismatched genetic background

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Free radicals are molecules that are potentially toxic to cells

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This typically becomes noticeable 2 to 3 weeks after the final dose, when circulating retatrutide levels have dropped below the therapeutic threshold