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The gut microbiota, defined as the diverse community of microorganisms residing in the human gastrointestinal tract, is increasingly recognized as a key mediator in this cross-system interaction

It acts at the GHRH receptor on pituitary somatotroph cells and has been studied for its role in stimulating endogenous growth hormone release and downstream IGF-1 production

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Second, the chemical barrier consists of different transporters for various substances

However, further research is needed to determine whether these metabolic effects are specific to IBM or whether they occur in other conditions as well

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