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This can sometimes lead to what's known as a Herxheimer reaction, or a 'healing crisis.' As toxins are mobilized from tissues and flushed out of the body, they can cause temporary symptoms like headaches, fatigue, skin rashes, andyou guessed itdigestive upset

FDA's 2024 review states the mechanism of action is still unknown, which limits how confidently any specific physiological effect can be predicted in humans

Using polygenic risk scores (PRS), researchers can evaluate an individuals genetic predisposition and estimate their risk of developing depression [299,300,301]

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Finally, the statistical models did not include BMI, as BMI data were only available in 39/53 asymptomatic individuals