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Notably, lactate-induced ALDH2-K52la in renal cells disrupts its interaction with PHB2, a critical mitophagy receptor, leading to PHB2 degradation, impaired mitophagy, and worsened kidney damage

Axonemal doublet microtubules can split into two complete singlets in human sperm flagellum tips

Self-renewal of hepatoblasts under chemically defined conditions by iterative growth factor and chemical screening

Post-translational regulation of RORtA therapeutic target for the modulation of interleukin-17-mediated responses in autoimmune diseases

Injection-site reactionsredness, swelling, minor discomfortare the most frequently reported adverse effects, occurring in 58% of users within 2448 hours post-injection

Sample volumes were normalized to 35 L with EPPS buffer (200 mM, pH 8), diluted with HPLC grade CH 3 CN (9 L), and then labeled (5 L of 20 g/L per sample) with the corresponding TMTsixplex Isobaric Mass Tag (Themo Scientific, #90064B)