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Sirtuins: guardians of mammalian healthspan

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The blind was not broken until the data were being analyzed at the completion of the study

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CR has also increased NAD + levels in the brain and liver of mice, where it also activated sirtuin 1 (Sirt1) in both tissues.[13,14] In these studies, sirtuins increase because either more NAD + is available, less NADH is inhibiting the reaction, or both

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