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The peptide is rapidly degraded by plasma peptidases, and in vivo half-lives reported across small-animal studies are in the minutes range

ACS Nano 12:32953310 Ju X, Fan D, Kong L, Yang Q, Zhu Y, Zhang S, Su G, Li Y (2021) Antimicrobial peptide Brevinin-1RL1 from frog skin secretion induces apoptosis and necrosis of tumor cells

Epithelia develop ex vivo a potential difference (PD) because they have two differential characteristics compared with other types of tissue: polarity and tightness

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