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While GHK-Cu is generally well-tolerated in topical research, certain contraindications or precautions should be considered, especially for systemic research or in specific populations: Systemic Research: For systemic applications, GHK-Cu is generally not recommended for subjects who are pregnant, breastfeeding, have active cancer, or suffer from Wilsons disease (a condition involving copper accumulation)

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[40] Iwabuchi, T., Ideta, R., Ehama, R., Yamanishi, H., Iino, M., Nakazawa, Y., Kobayashi, T., Ohyama, M., & Kishimoto, J

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