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Similarly, BCAA elevation in DKD reflects both impaired renal catabolism (reduced mitochondrial BCKDH activity) and insulin resistance-driven alterations (133), with standard eGFR adjustment being insufficient as GFR lies on the causal pathway between metabolites and outcomes

Current research has found that ferroptosis caused by the downregulation of the Nrf2/HO-1/GPX4 pathway is closely associated with diminished ovarian reserve (Niu et al., 2023