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Furthermore, L-citrulline is not extracted from the systemic circulation for hepatic clearance [3]

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10.1152/physrev.00023.2017 93 YanC.ZhangY.ZhangX.AaJ.WangG.XieY

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In the next step of the one-carbon cycle, SAM donates its methyl group to a variety of acceptor molecules, leading to S-adenosylhomocysteine (SAH) formation ( Figure 1 ) (Lu, 2013)

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