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Similar to the hippocampus, a significant portion of cerebellar Purkinje cells in the CN group exhibited dark appearance with a significant cell shrinkage and cytoplasmatic condensation, which is indicative of cellular stress or degeneration

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By activating the lactate transporter Slc5a12 on CD4 + T cells and inhibiting the expression of hexokinase 1 (HK1), lactate accumulation in synovial fluid (SF) reduced glycolytic flux in T cells and promotes FAS, which raises IL-17 production (152)