Recent studies have highlighted astragaloside IV (AS-IV)the principal bioactive component of Astragalus membranaceus as a particularly promising candidate
The nasal mucosa is highly vascularized, allowing absorption directly into circulation, and some evidence suggests nasal administration may provide more direct central nervous system access via the olfactory pathway
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2.3 Glutamate modulators 2.3.1 Riluzole Glutamate excess can induce CNS neurotoxicity, leading to interest in developing a class of drugs which modulate glutamate activity directly or indirectly (Grados et al., 2015)
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There's also a mild physiological case: some repair and detox processes are more active during sleep
