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Biomaterials used for bone tissue engineering generally include biodegradable polymers, bioceramics, bioactive glasses, and composite materials that integrate both components.Polymers such as poly (lactic-co-glycolic acid) (PLGA) and polycaprolactone (PCL) offer controllable degradability, flexibility, and ease of processing, making them ideal for drug encapsulation and sustained release.Bioceramics, including hydroxyapatite (HA) and -tricalcium phosphate (-TCP), exhibit excellent osteoconductivity and chemical similarity to natural bone minerals, facilitating cell adhesion and bone integration

doi: 10.1002/jcb.28870 68

Obach, M

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In conclusion, we show that APAP toxicity in HepG2 cells is largely independent of oxidative stress, and is linked instead to a decoupling of glycolysis from the TCA cycle, lactic acidosis, reduced NADPH production, and subsequent suppression of the anabolic pathways required for rapid growth