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Combining peptides in preclinical protocols is common when modeling multifactorial venous disease, but dose timing and interaction effects require careful experimental design

10.1186/s10020-025-01064-1 130 WardN

For instance, Buhimish et al

Protective effect of Pentadecapeptide BPC 157 against experimental colitis involves neuropeptides neurokinin1 receptor/substance P system activation: role for mast cells degranulation inhibition via mitogenactivated protein kinases pathways modulation Cell Signal 27(5): 9961007 Kiefer JW Jr., Lee CLF

The findings in the present study provide the proof of concept for using PGPIPN as a potential therapeutic agent for the treatment of AFLD

Furthermore, an in-depth Dynamic Cross-Correlation Matrix (DCCM) analysis elucidated the intricate residual dynamics of GR upon binding with the respective ligands within the active pocket