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Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3

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Importantly, systemic iron overload leads to excessive iron deposition in lung cells, particularly in AECIIs, alveolar macrophages, vascular smooth muscle cells, and ciliated airway epithelial cells (Figure 1) (Neves et al., 2017)

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