Deng D, Xia J, Cao J, Qu L, Tian J, Qian Z, Gu Y, Gu Z
We observed a pronounced vehicle-corrected weight loss of 15.2% in the group treated with GLP-1MK-801 compared with 3.5% in the group treated with the parent GLP-1 analogue after 9 days of treatment, underscoring that the weight-lowering efficacy of the conjugate is intact in the absence of functional MC4R signalling (Fig
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Therefore, screening for lead compounds able to activate this essential enzyme might protect neuronal cells from damage and slow the disease progression