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Several preclinical studies indicated that MSCs with enhanced CXCR4 expression after genetic engineering, treatment with ALF rat serum or stimulation with inflammatory cytokines such as TNF- and IL-1/3 showed better homing in vivo (101106)

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This study documented in humans the variability of the leak pathway in response to systemic inflammation versus the constancy of the pore pathway, and that very large solutes cannot penetrate the paracellular barrier, even in the presence of inflammation

In: Bergmeyer HU, editor

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