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PlateletNET aggregates further amplify coagulation and inflammatory signaling, creating a feed-forward loop that compromises capillary perfusion and tissue oxygen delivery [56]

In the enzymatic pathway, the lipoxygenase (LOX) family plays a central role: ALOX12 is essential for p53-mediated ferroptosis and serves as a key effector downstream of solute carrier family 7 member 11(SLC7A11) ( 2.2.3 Coordinated regulation by signaling pathways In periodontitis, aberrant activation of the Hippo-YAP pathway promotes iron accumulation and lipid peroxidation synergistically by upregulating TFRC and ACSL4 while downregulating GPX4, thereby accelerating ferroptosis-induced periodontal tissue damage ( Clinical evidence indicates that gingival tissue biopsies from periodontitis patients show significantly upregulated ACSL4 protein expression, and gingival crevicular fluid exhibits abnormally elevated concentrations of 4-HNE and MDA

A Clinical Nomogram Predicting Pathologic Lymph Node Involvement in Esophageal Cancer Patients

Stimulation of tumor growth in adult rats in vivo during an acute fast

Thus for drugs known to undergo enterohepatic recirculation, the need for therapeutic drug monitoring may be necessary to ensure optimal dosing and to avoid adverse effects

Teh et al., 2015)