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It was observed that the overexpression of PINK1 in a Drosophila model of HD resulted in the amelioration of Parkin-mediated mitophagy defects and the attenuation of mHtt-induced neurotoxicity

S-adenosylmethionine acts as a universal methyl donor for several reactions, being the major biological methylating agent ( Before producing methylation potential, Met may also play an indirect role in polyamine (putrescine, spermidine, and spermine) synthesis ( Figure 1 )

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