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The process of glucuronic acid conjugation usually terminates the pharmacological activity of drugs but in some cases drug is converted into an active form

however, it often causes nephrotoxicity, limiting its use

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[DOI] [PMC free article] [PubMed] [Google Scholar] 18.Pedroso JAB, Dos Santos LBP, Furigo IC, Spagnol AR, Wasinski F, List EO, Kopchick JJ, and Donato J Jr., Deletion of growth hormone receptor in hypothalamic neurons affects the adaptation capacity to aerobic exercise