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Research published by Gwyer et al

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In another study, historic sera, which were able to neutralize 229E sequences from the time of collection, failed to neutralize strains isolated 817 years later

The differences lie in convenience, comfort, and side effect profiles

With the previously mentioned B12 absorption challenges, it is not advisable to use forms that are either unstable (adeno-B12) or forms (cyano) that take more energy to convert into the active methyl-B12