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doi:10.3109/03009749709105320

Research in rat pinealocytes showed that epitalon upregulates two key enzymes in the melatonin synthesis pathway AANAT and pCREB directly stimulating endogenous melatonin production at the cellular level

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That determination is not bound by the committee's vote but the agency has historically aligned with clear PCAC consensus

Springer, pp 30773097 Li J et al (2025) Effects of nutritional supplements on endurance performance and subjective perception in athletes exercising in the heat: a systematic review and network meta-analysis