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In an often-cited 1993 study, GHK-Cu increased the accumulation of connective tissue in experimental wounds in rats, supporting a real role in repair

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213,214 The accumulation of ROS in the cell leads to unfolded protein response and induces endoplasmic reticulum stress

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However, neither the international literature nor the national literature sufficiently emphasises the use of retrofitting as an option, and it also shows that governments and landowners have a negative bias towards retrofitting