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In OA and other chronic degenerative disorders, cells and tissues also undergo shifts in energy metabolism and biosynthetic pathways to adapt to pathological microenvironments characterized by hypoxia, inflammation, mechanical stress, and nutrient limitation ( 3.1 Lipid metabolic reprogramming 3.1.1 PUFAs and lipid peroxidation Lipid peroxidation is the central event in ferroptosis

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244,246 These systems have helped improve the credibility and accessibility of standardized herbal products across the European Union

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