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The resulting systemic cytokine storm coincides with ROS attacking tight junction proteins in capillary endothelial cells, inducing microcirculatory leakage [412]

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Administration of liposomal-based Pde3b gene therapy protects mice against collagen-induced rheumatoid arthritis via modulating macrophage polarization

Similarly, interventions such as fluoxetine or metformin restore gut microbial diversity, increase beneficial bacteria (e.g., Akkermansia muciniphila ), and raise 5-HT levels (Xie et al., 2025

Human renal gene expression data To compare gene expression data in healthy individuals and patients with AKI, we used an approach published previously of merging scRNA data from KPMP and the Human Kidney Single Cell Transcriptome [18]

Moreover, hydrogels can provide an excellent storage environment for stem cells