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Its unique stability and oral bioavailability in animal models, as demonstrated in early research, differentiate it from many other peptides which often require parenteral administration for systemic effects

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Bile duct carcinomas usually metastasize to the regional lymph nodes, lungs and peritoneum, kidneys, heart, adrenal glands, eye, and bone.1, 60 Bile duct carcinoma can be intrahepatic or extrahepatic, but rarely occurs within the gallbladder

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