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Collectively, these findings represent the first biomarker/molecular difference that has been found to be different between children affected with konzo as compared to unaffected individuals and may serve as a biomarker for not only disease, but to identify children that harbor increased risk for disease susceptibility and severity

ACS Appl Mater Interfaces 13(8):95009519 Li L et al (2021) Nucleic acid aptamers for molecular diagnostics and therapeutics: advances and perspectives

Moreover, the metal nanoprodrug NPS-G-Fe produced by coordinating Fe 3+ and gallic acid (GA) with Ce6 in photoactivated Pt(IV) containing nanoprodrug and then coating with PEG-modified chondroitin sulfate (PEG-CS) can lead to iron dissociation under acidic tumor microenvironment conditions, and NPS-G-Fe can promote macrophage polarization to M1 phenotype after radiotherapy thereby enhancing anti-tumor efficacy (35)

Under high temperatures, exogenous SA has been shown to induce the gene expression of PAL and lead to the accumulation of polyphenols in grapes, thus improve resistance to high temperatures [50]

Exp Neurol 150:4044 Sofic E, Lange KW, Jellinger K, Riederer P (1992) Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease