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One cause of such a cytokine storm is an imbalance of the ratio between ACE1 (the pro-inflammatory mediator) and ACE2 (the anti-inflammatory mediator)

10.1155/2015/401630 16 AshorA

doi: 10.1074/jbc.M410873200

X-box binding protein 1 (XBP1), a key regulator of the ERS response, along with HRD1, shows elevated expression during I/R injury

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