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Mechanistically distinct from other forms of cell death, cuproptosis is characterized by the direct binding of copper to lipoylated enzymes in the mitochondrial tricarboxylic acid (TCA) cycle, leading to proteotoxic stress and subsequent cell death, independent of classical apoptotic signaling [3]

At L5S1, we found substantially lower NP-T1 values in cLBP patients than controls in age-adjusted models, suggesting that age-adjusted NP-T1 values could be used to distinguish pathologic degenerative changes associated with cLBP from normal disc aging, particularly in younger individuals

Abbas AK, Lichtman AH, Pillai S

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They band together in chains to form the stuff from which life is born