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However, the pathophysiological role of this response to APAP is still controversial-whether it contributes to the progression of liver injury or acts as cellular defense against toxicity [13], [20], [48], [121],[121], [13], [20], [48]

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Ecancermedicalscience 17:1499 Moreno S, Farioli-Vecchioli S, Ceru M (2004) Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS

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doi: 10.1096/fj.202002178R 36 IshikawaHYoshinoOTaniguchiFHaradaTMomoedaMOsugaYet al