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45 The second step is an irreversible rate-limiting reaction catalyzed by branched-chain -keto acid dehydrogenase (BCKDH), which is phosphorylated and inactivated by the specific kinase BCKDH kinase (BCKDK) and dephosphorylated and activated by Protein phosphatase 1 K (PPM1K)

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Diabetics need to take insulin because their bodies dont produce enough (or any) of it, but its also used by bodybuilders to facilitate protein synthesis (i.e., muscle growth) by enhancing nutrient storage and inhibiting protein breakdown

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Nutr Cancer 21, 3346, doi: 10.1080/01635589409514302 (1994)

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