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Chemiluminescent assays have been used to show a negative association between an increase in ROS levels and sperm parameters

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16 Biomarkers of oxidative stress have been reported in many neurological and psychiatric disorders, including Alzheimer's disease, 17 Parkinson's disease, 18 schizophrenia, 19, 20 bipolar disorder 21 and alcoholism, 22 and may reflect a common underlying pathophysiological mechanism