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Upon binding to IL12R, the JAK2 was linked to IL12R2, and then STAT4 was phosphorylated, after which the dimerized STAT4 could be transferred to the nucleus to alter gene expression (48, 49)

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Additionally, a troubling increase in CRC cases has been observed in Asia, which now has the highest CRC incidence (51.8%) and mortality (52.4%) per 100,000 population worldwide (4)

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The results obtained indicate that S