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In vitro experiments have shown that paeoniflorin can upregulate the expression levels of SLC7A11, thereby inhibiting ferroptosis in renal tubular epithelial cells, providing a potential therapeutic strategy for protecting kidney tissues (182)

In addition, IF has been shown to modulate the limbic dopaminergic and thyrotropin-releasing hormone (TRH) systems, which regulate feeding behavior and hypothalamic-pituitary-thyroid (HPT) axis activity [62]

Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas

Glutathione injections are generally well tolerated

13 , e1005752 (2017)

Ubiquitination and deubiquitination affect intracellular protein homeostasis by altering the ubiquitin chain of substrate proteins, influencing their degradation by the proteasome, and modulating downstream signaling pathways