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Drosophila and mice with the Y314S variant both showed degeneration of dopaminergic neurons and locomotor defects (Lin et al., 2020), providing direct evidence for the involvement of cIII in PD pathogenesis

This action is bacteriostatic rather than bactericidal, meaning bacterial growth is prevented rather than organisms being directly destroyed

tract when you have leaky gut. We use prebiotic fiber (foods or powders) to feed the good bacteria and (for non-CIRS patients) a little bit of good yeast to re-create a healthy gut microbiome

Deconinck et al., 2021

Apaf-1 is an evolutionarily conserved DNA sensor that switches the cell fate between apoptosis and inflammation

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