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Evidence indicated that the dysregulation in mitochondrial function would have negative effects on the both hemostasis of cellular ions and the stability of the cellular membrane, leading to cortex excitability(29, 30)

PAOD, peripheral arterial occlusive disease

Melatonin and metformin failed to modify the effect of dacarbazine in melanoma

Addressing these gaps requires integrated genomic, proteomic, and preclinical studies to dissect the molecular determinants of p53s dual role and resolve its clinical utility in ferroptosis-based cancer treatment

10.1007/s00344-024-11472-y 287

Cynthia Thurlow, NP has discussed the limitations of oral delivery systems for molecules that require precise systemic circulation