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References [1] Sekhar RV, Patel SG, Guthikonda AP, Reid M, Balasubramanyam A, Taffet GE, Jahoor F

25-hydroxycholesterol, a negative regulator of cholesterol biosynthesis, downregulates CYP51A1 mRNA in adrenocortical H295R and HepG2 cells

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Individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia type 2 (MEN2) should discuss this with their clinician before considering any GLP-1based therapy, and should be alert to symptoms such as a neck lump, hoarseness, or difficulty swallowing