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Altogether, it appears that therapeutic APAP treatment could generate perturbation of SAA and GSH metabolism leading to lower Cys availability for physiological functions

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Takeuchi K, Okada M, Ueshima K, Ohuchi T, and Okabe S (1993)

Would restoring mitochondrial functioning improve conditions associated with mitochondrial dysfunction? Restoring glutathione Restoring glutathione in cells was not straightforward because glutathione cannot work if taken orally for the same reasons that diabetic patients cannot eat insulin

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