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Following FOXO4 displacement, the released p53 undergoes nuclear export and mitochondrial translocation, activating the intrinsic apoptosis pathway via BAX upregulation and BCL-2 downregulation, culminating in caspase-3 cleavage and apoptotic cell death

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The ggplot2 R software package was used to construct volcano plots for data visualization

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those starting below 8% fell by about 1.5 to 2 points. Tirzepatide lowers glucose mainly by improving insulin sensitivity rather than forcing the pancreas to release more insulin