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Consistent with the knockdown results, BAY-876 or SU056 dampened cell proliferation without significant cell death, whereas dramatic cell death was observed in the combination treatment group (Fig

By contrast, ICA exerted no protective effect in GPX4-silenced SW1353 cells, indicating that the drug ameliorates ferroptosis and cartilage injury via the SLC7A11/GPX4 pathway (153)

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