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Addressing the rising incidence of azole-resistant Aspergillus fumigatus , researchers also developed novel inhibitors targeting Af DHODH, a key enzyme in pyrimidine biosynthesis, yielded 13 candidate molecules, with two demonstrating sub-100 M activity in vitro ( Li K
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Failure of detoxification will result in ROS reacting with cellular components and ultimately leading to impaired cellular function [11]
[DOI] [PubMed] [Google Scholar] 170.Bao W., Li K., Rong S., Yao P., Hao L., Ying C., Zhang X., Nussler A., Liu L
To evaluate the ability of molecules to interfere with aggregation of hCC while informing about cellular toxicity, cells were generated that produce and secrete WT and L68Q-hCC producing high-molecular weight complexes formed from the mutant protein