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Studies show that B12 deficiency is linked to an increased risk of developing depressive symptoms, mood disorders, and psychosis

In some embodiments, the otic formulation or composition comprises between about 0.01% to about 3% by weight of the poloxamer

In particular, many of these drugs, similar to statins, are regularly seen and prescribed for chronic metabolic syndromes

doi:10.1186/s13075-023-03043-5

Short peptides often enter tissues more readily, producing local changes without strong systemic hormone shifts

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