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Phase 2 study of anti-EGFR rechallenge therapy with panitumumab with or without trametinib in advanced colorectal cancer

Biochim Biophys Acta 139(2):319327 Nunes T, Rocha JF, Vaz-da-Silva M, Igreja B, Wright LC, Falco A, Almeida L, Soares-da-Silva P (2010) Safety, tolerability, and pharmacokinetics of etamicastat, a novel dopamine--hydroxylase inhibitor, in a rising multiple-dose study in young healthy subjects

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Phase 3 TRIUMPH-4 showed 28.7% weight loss at 68 weeks, substantially exceeding CagriSema's 20.4% at 68 weeks

Disease-dependent reciprocal phosphorylation of serine and tyrosine residues of c-Met/HGF receptor contributes disease retardation of a transgenic mouse model of ALS