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Since the above-mentioned eryptosis-associated detrimental effects are mainly associated with PS exposure, the eryptosis-targeting drugs should prevent PS externalization

Elevated protein expression of H3K27me3 and H3K4me2 and mRNA expression of related methyltransferase genes SUV39H2 , SETDB1 , and EZH2 result in increased histone methylation [94]

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Antitumor effects of 5-FU are primarily mediated by the suppression of thymidylate synthase (TS), which disrupts the intracellular deoxynucleotide pool essential for DNA replication

doi: 10.1016/j.neuroscience.2007.09.083 182

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