Systemic bioavailability of orally consumed glutathione is low because the molecule, a tripeptide, is the substrate of proteolytic enzymes (peptidases glutamyl transpeptidase GGT) of the alimentary canal, and because of the absence of a specific carrier of glutathione at the cell membrane site
Karampathsis, E
Hu Q, Su H, Li J, Lyon C, Tang W, Wan M, et al
The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
While these findings are promising, human clinical trials are still needed to confirm its effectiveness in treating cardiovascular injuries (7)
[DOI] [PMC free article] [PubMed] [Google Scholar] 908.Zhao S., Wang X., Zhu C., Zhang Y., Zhang J., Tong Q