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Some studies have concurrently employed cerebral blood flow perfusion imaging, revealing that the hypometabolic regions extend beyond those with reduced perfusion, suggesting the presence of intrinsic mitochondrial dysfunction in neurons (165)

PMID: 24384493

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doi: 10.1002/bjs.4786 84 OrabuezeIMasucciACluzetV

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Pioglitazone inhibits diabetes-induced atrial mitochondrial oxidative stress and improves mitochondrial biogenesis, dynamics, and function through the PPAR-/PGC-1 signaling pathway