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The Wnt/-catenin pathway benefits ferroptosis by promoting -catenin binding to TCF/LEF transcription factors, which in turn reduces GPX4 activity and increases lipid peroxidation ( 4 Effects of plant polysaccharides on cancer treatment via ferroptosis Polysaccharides possess significant anticancer potential by inhibiting cancer cell growth, regulating immunity, improving the cancer microenvironment, and overcoming drug resistance

Clin Chem 40 : 857858