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HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer's disease

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Ongoing research continues to explore its potential applications in nonalcoholic fatty liver disease (NAFLD), where a 2019 trial published in Lancet HIV demonstrated a 32% relative reduction in hepatic fat fraction over 12 months

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*JAMA*, 300(18), 2123-2133

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Fernandes BS, et al

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