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For grade 3 toxicities, ICIs are held, and high-dose corticosteroids are initiated at an initial dose of 1 to 2 mg/kg day (prednisone or equivalent)

doi: 10.1017/s1461145702003097

Reduced Glutathione (GSH) is the biologically active form

While high doses of vitamin C generally arent considered harmful, they could cause gastrointestinal discomfort

CD38 has been described as a negative prognostic marker in chronic lymphocytic leukemia and as a surface marker in multiple myeloma 41,298 In addition, CD38 may regulate the sensitivity of pancreatic cancer cells to FK866 treatment