A substance or method will be considered for inclusion on the WADA Prohibited List by the WADA List Expert Advisory Group if the substance or method meets two of the following three criteria: It has the potential to enhance or enhances sport performance
Here is what we know, what we do not know, and where the gaps are
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Interestingly, the closest relatives of many mtDNA-modifying enzymes, such as mtDNA polymerase, are bacteriophage proteins [94], suggesting that an infection of the mitochondrial ancestor contributed to the development of mtDNA maintenance machinery
Most preclinical studies have relied on HK-2 cells (human proximal tubular epithelial cells) and generic animal models, but the cell type-specific contribution to CIN-related ferroptosis is severely understudied
Researchers studying NAD+ biology or methyl-donor pools should evaluate primary sources directly and note that NNMT inhibition has distinct mechanistic implications compared to direct NAD+ precursor supplementation with molecules like NMN or NAD+ itself
